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Innovation Corner

The Alliance Innovation Corner is a regular publication of The Alliance National Innovation Council that champions novel approaches, groundbreaking strategies and transformative initiatives to advance the field of donation and transplantation. Through real-world accounts and insightful narratives, this series explores the shared experiences of community leaders, spotlighting lessons learned along the way.

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Some legacy resources on this website may refer to UNOS in place of the OPTN, reflecting common usage at the time of publication when the two were often used interchangeably. In recent years, significant work has gone into distinguishing these as separate entities: the OPTN is the nationwide organ transplant network established by federal law, while UNOS is one of several organizations currently under contract to support OPTN operations. We’ve preserved these resources as originally published, but recommend referring to current terminology for the most accurate understanding of each organization’s role.

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Jon Duke, MD and MS Director of the Center for Health Analytics and Informatics and Principal Research Scientist for Georgia Tech Research Institute, delivered a compelling presentation exploring the accelerating role of generative artificial intelligence (AI) in healthcare. This content was presented at The Alliance National Innovation Forum: Harnessing Artificial Intelligence on May 8, 2025.

AI in Healthcare: The Good, The Bad, and The Likely

AI is already changing how care is delivered and offering a glimpse into where it may lead next. As its capabilities continue to evolve, Large Language Models (LLM) and multi-functional AI agents have the potential to streamline workflows, improve decision-making and expand access to care. LLM’s designs have advanced to “Chain-of-Thought” and combined mini-LLM models through fundamental steps such as research, prediction, sentence variety, and human modification. Practical frameworks were introduced to ensure careful planning was implemented, keeping AI’s transformative promise safe and ethical.

The Good: Addressing Challenges Through Innovation

  • Chart Summarization and Note Generation: AI helps to reduce documentation burden, freeing up clinician time and alleviating burnout. For reference, 54% of doctors say they are burned out and 88% are moderately to severely stressed.
  • AI-assisted Patient Intake Tools: AI captures relevant medical history across languages and literacy levels, potentially increasing accuracy and comfort for patients. To achieve accurate sources of “truth,” a common solution is Retrieval Augmented Generation (RAG) where models pull knowledge solely from documents you give it.

Early studies suggest that AI-generated patient communications, such as follow-up messages, may outperform clinician-written ones in clarity and empathy. As AI improves in synthesizing clinical evidence, it could enhance decision support and speed the adoption of best practices.

The Bad: Areas of Concern and Caution

  • Inaccurate Outputs: There is a possibility that AI may generate incorrect information; if left unchecked, this could lead to misguided clinical decisions.
  • Biases in Training Data: Learning procedures may perpetuate disparities, particularly for underrepresented groups. With clinical decision support, the judgment a provider makes for a patient may not translate into inputs to the AI mode. Without the ability to hear, see, or sense, LLM “hallucinations” increase.
  • Ethical and Legal Uncertainties: AI’s growing role raises complex questions, especially when its recommendations influence clinical judgment. It’s important to note that current generation decision support is poorly accepted by physicians.

Over time, reliance on AI could lead to a lack of accountability, weakened clinical reasoning, negative patient sentiment, and disrupted traditional training. If AI substitutes human interaction, it may contribute to a deterioration of the patient-provider relationship and undermine the trust that supports it.

The Likely: What’s Coming in the Near Future

  1. AI agents, which combine tools, memory, and reasoning, will likely become central to routine healthcare interactions within three to five years. Agents combine models, tools, persistent memory, and interaction with people or other agents to carry out tasks.
  2. Virtual AI providers could expand access to care, particularly for underserved populations, with clinicians overseeing escalated cases.
  3. Medical training will evolve to reflect AI’s growing presence, requiring new competencies and redefining roles across specialties. As AI decision support evolves more comprehensively in its insights and more authoritatively in the way it communicates information, uptake will increase.

Implications for the Field

The adoption of AI will not be confined to technical upgrades. It will reshape workflows, redefine clinical roles, and prompt systemic change. As AI tools increasingly support core functions such as documentation, communication, and decision-making, healthcare organizations must invest in new governance structures, training models, and ethical safeguards to guide responsible implementation.

Helpful Resources

Check out our Alliance On-Demand Learning Pathways, featuring “Harnessing Artificial Intelligence.”

 

Questions & Comments

Please send all questions and/or feedback to info@organdonationalliance.org.

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Illuminating Innovation AI In Healthcare Good, Bad, And Likely

A Special Thanks to This Series’ Contributors

Jon Duke 2
Speaker
Jon Duke
MD, MS
Georgia Tech Research Institute (GTRI)
McKinley Walsh
About the Editor |
McKinley Walsh

McKinley joins the Alliance with over five years of experience managing large-scale programs, national events, and developing public health programs. She began working at the Centers for Disease Control and Prevention (CDC), first as a field assignee to the Mississippi State Department of Health in Jackson, Mississippi, where she worked with the Women and Children’s Health. She then joined the Sickle Cell Data Collection (SCDC) program, where she managed 16 grantees over two years.

She graduated from Ithaca College with a B.S. in Public and Community Health, where she studied how to analyze the social, economic, and environmental factors that impact health and develop strategies to address key issues. She is excited to continue working through advocacy, education, and research with the Alliance.

Samaya
About the Editor |
Samaya Agarwal

Samaya Agarwal is a junior at Midtown High School in Atlanta, GA. She interned with The Alliance in summer 2025, developing a series of “Illuminating Innovation” issues for an exploration of artificial intelligence in healthcare.

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