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Innovation Corner

The Alliance Innovation Corner is a regular publication of The Alliance National Innovation Council that champions novel approaches, groundbreaking strategies and transformative initiatives to advance the field of donation and transplantation. Through real-world accounts and insightful narratives, this series explores the shared experiences of community leaders, spotlighting lessons learned along the way.

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A Note About Content

Some legacy resources on this website may refer to UNOS in place of the OPTN, reflecting common usage at the time of publication when the two were often used interchangeably. In recent years, significant work has gone into distinguishing these as separate entities: the OPTN is the nationwide organ transplant network established by federal law, while UNOS is one of several organizations currently under contract to support OPTN operations. We’ve preserved these resources as originally published, but recommend referring to current terminology for the most accurate understanding of each organization’s role.

Laura Epstein, Founder and CEO of Pulse Charter Connect, explored how artificial intelligence (AI) and machine learning (ML) are transforming the speed, safety, and scalability of organ transport logistics. Epstein detailed how her team is applying cutting-edge technology to address longstanding inefficiencies in transplant delivery. This content was presented at The Alliance National Innovation Forum: Harnessing Artificial Intelligence on May 8, 2025.

Logistics & Transportation in AI-Driven Care

AI and machine learning can streamline transplant logistics by anticipating disruptions like weather, aircraft availability, and scheduling changes. By enabling real-time, data-informed decision-making, these tools help improve coordination and reliability across the entire transportation process.

Challenges

  • Fragmented, manual logistics processes
  • Unpredictable delays due to weather, traffic, or last-minute changes
  • Limited situational awareness across air and ground transport systems

Innovations Introduced

Predictive Disruption Modeling AI integrates real-time FAA alerts, weather APIs, airport congestion data, and historical patterns to forecast potential disruptions.

  • Smart Provider Matching: Algorithms assess aircraft proximity, past performance, compliance, and mission-specific factors to determine the optimal transport solution. The most suitable aircrafts are selected, which reduce cost and increase speed.
  • Automated Routing: AI evaluates aviation-specific constraints, such as runway length, historical performance, and flight time, to generate the most efficient route.
  • Real-Time Alerting: Systems monitor active missions, issuing alerts for deviations such as weather shifts or mechanical issues.
  • Data Integration: AI synthesizes structured clinical metrics and unstructured notes to ensure that logistical decisions align with clinical priorities.

Evidence and Qualitative Benefits

  • Weather Forecast Accuracy: Predictive models using APIs from sources like NOAA and The Weather Company achieve 85–95% accuracy for 6–12 hour windows. This enables AI to reroute missions hours before a human coordinator might identify a problem, such as an approaching cold front.
  • Airborne GPS Tracking: FAA and FlightAware offer about 90% confidence in delay predictions and timing. Real-time alerts flag issues like mechanical problems, traffic, or weather changes, enabling quick adjustments.

Outcomes and Impacts

  • Greater reliability and precision in mission planning, resulting in lower non-use rates
  • Reduced cold ischemia time and fewer missed transplant opportunities
  • Increased transplant capacity through more efficient resource use
  • Enhanced transparency and accountability among transport providers, including substantial resource savings

Implications for the Field

AI is designed to support, not replace, clinical coordinators. By easing the logistical burden, AI enables teams to focus on patient care and make informed, urgent decisions. Looking ahead, she envisioned more collaborative learning models, better system integration, and expanded access for rural and underserved communities.

Helpful Resources

Check out our Alliance On-Demand Learning Pathways, featuring “Harnessing Artificial Intelligence.”

Questions & Comments

Please send all questions and/or feedback to info@organdonationalliance.org.

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Illuminating Innovation Logistics & Transportation

A Special Thanks to This Series’ Contributors

McKinley Walsh
About the Editor |
McKinley Walsh

McKinley joins the Alliance with over five years of experience managing large-scale programs, national events, and developing public health programs. She began working at the Centers for Disease Control and Prevention (CDC), first as a field assignee to the Mississippi State Department of Health in Jackson, Mississippi, where she worked with the Women and Children’s Health. She then joined the Sickle Cell Data Collection (SCDC) program, where she managed 16 grantees over two years.

She graduated from Ithaca College with a B.S. in Public and Community Health, where she studied how to analyze the social, economic, and environmental factors that impact health and develop strategies to address key issues. She is excited to continue working through advocacy, education, and research with the Alliance.

Samaya
About the Editor |
Samaya Agarwal

Samaya Agarwal is a junior at Midtown High School in Atlanta, GA. She interned with The Alliance in summer 2025, developing a series of “Illuminating Innovation” issues for an exploration of artificial intelligence in healthcare.

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