Casey Humphries, MS, is the Portfolio Strategy Manager at United Network for Organ Sharing (UNOS), where she leads critical initiatives aimed at improving organ allocation, system performance, and the overall effectiveness of the national transplant network. With more than a decade of experience in project and portfolio management, she is known for bringing structure, clarity, and collaborative energy to some of the most complex challenges in the field.
She was nominated for The Alliance 40 Under 40 by Tess Gallagher, Communications Manager at UNOS. Gallagher described Humphries as “an indispensable strategic leader,” noting her pivotal role in orchestrating multi-stakeholder initiatives that advance the UNOS mission. “Casey has a gift for bringing diverse voices to the table, setting shared goals, and moving projects forward with discipline and heart,” she wrote.
At UNOS, Humphries oversees a broad portfolio of national projects that touch every part of the donation and transplant continuum. Her efforts have supported policy development, technological innovation, and process improvements designed to increase efficiency and transparency. Colleagues credit her with being a steadying force in high-pressure environments and a catalyst for positive change across multidisciplinary teams.
Her career is distinguished by an ability to blend strategic thinking with operational follow-through. She is not only a facilitator of big ideas but also a builder of practical solutions that endure. Casey’s thoughtful leadership and deep understanding of the transplant system have made her a trusted partner to clinicians, administrators, and policymakers alike.
Casey Humphries represents the best of systems-level leadership. She listens carefully, builds consensus, and turns vision into measurable impact. Her contributions continue to shape how the transplant community works together to save and improve more lives.